Photoacoustic Imaging

Photoacustic imaging (PA) integrates the sensitivity of optical imaging with the resolution of high-frequency ultrasound, to provide insights into tissue microenvironment and hemodynamic changes,  addressing the needs of different biological research areas. This hybrid imaging modality is able to detect and quantify endogenous photoacoustic signals of oxy- and deoxy-hemoglobin, as well as photoacoustic contrast agents like gold nanorods and carbon nanotubes that have emerged in recent years as specific and customizable agents for cancer detection and  marking of genetic mutations cancer-associated,  improving early detection and treatment of neoplasias.

Visualsonics VEVO LAZR
This Photoacoustic Imaging platform allows multispectral imaging with multiple wavelengths (680-970 nm), to detect and quantify signals of oxy- and deoxy-hemoglobin as well as fluorescent dyes with high-resolution, high sensitivity and specificity – even in deep tissues – with real-time and 3D imaging capabilities. Vevo LAZR gives researchers the opportunity to study a wide range of animal models from embryos to adults, with the advantages of inherent co-registration in both 2D and 3D planes of photoacoustic and anatomical images, facilitating biomarker development and longitudinal studies in translational research.
It is integrated with the VEVO 2100 US imaging systems in order to offer an ecographic morphologic background to the photoacoustic image.
Real time imaging of deep tissues (max 1 cm).
Two different transducers (13-24 MHz with axial resolution of 75 microns, and 32-55 MHz with axial resolution of 44 microns).
Multispectral scan (range 680-970 nm).

Available at the centre for Preclinical Imaging in Colleretto Giacosa, at IFC-CNR in Pisa and at IBB-CNR in Naples.


LOIS 3D combines light and sound to produce a three dimensional image of tissue-simulating phantoms, small animals, and other types of tissue submerged in the imaging module. LOIS-3D is the first system of its kind to produce comprehensive information based upon volumetric optoacoustic tomography depicting the absorbed optical energy (blood distribution and its oxygenation). This provides an extremely rich set of complementary anatomical and functional 3D images.

Available at the University of Torino, Torino.