Research activity: projects and publications

UNITO - Selected publications and grants from last 5 years

  1. Geninatti Crich S, Terreno E, Aime S. “Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis”,  Adv Drug Deliv Rev 2017, doi: 10.1016/j.addr.2017.08.004. [Epub ahead of print] [11.764]
  2. Longo DL, Stefania R, Callari C, De Rose F, Rolle R, Conti L, Consolino L, Arena F, Aime S.” Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced  Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy”,  Adv Healthc Mater. 2017, 6(1) [9.034]
  3. Hu H, Arena F, Gianolio E, Boffa C, Di Gregorio E, Stefania R, Orio L, Baroni S, Aime S. “Mesoporous silica nanoparticles functionalized with fluorescent and MRI reporters for the visualization of murine tumors overexpressing αvβ3 receptors”, Nanoscale. 2016, 8(13):7094-104 [7.367]
  4. Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-Crich S, Giovenzana GB,  Aime S. “Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners. Biomaterials”, 2016, 75:47-57 [8.402]
  5. Di Gregorio E, Ferrauto G, Gianolio E, Lanzardo S, Carrera C, Fedeli F, Aime S. “An MRI Method To Map Tumor Hypoxia Using Red Blood Cells Loaded with a pO2-Responsive Gd-Agent”, ACS Nano 2015 9:8239-48
  6. Reineri F, Boi T, Aime S. “ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate” Nat Commun. 2015, 6:5858
  7. Ferrauto G, Digilio G, Delli castelli D, Di Greogorio E, Langereis S, Burdinski D, Grull H, Terreno E, Aime S. “Lanthanide loaded erithorictes as highly selective Chemical Exchange Saturation Transfer MRI agents”, J. Am. Chem. Soc. 2014; 136 (2), pp. 638-641.
  8. Sanino A.,  Dastru W., Mainini F.,  Castelli D.D., Aime  S.,  Terreno E. "Polymeric Vesicles Loaded with Gadoteridol as Reversible and  Concentration-Independent Magnetic Resonance Imaging Thermometers" JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 2014, 10(8), 1620-1626.
  9. Longo D.L., Sun P.Z., Consolino L., Michelotti F.C., Uggeri F., Aime S. "A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Mapping with lobitridol" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2014, 136(41), 14333-14336
  10. Geninatti Crich S., Alberti D., Szabo I., Aime S., Djanashvili K., "MRI visualization of melanoma cells by targeting overexpressed sialic acid with a GdIII-dota-en-pba imaging reporter "  ANGEWANDTE CHEMIE - INTERNATIONAL EDITION  2013, 52(4), 1161-1164
  • H2020-INFRASUPP-2014-2: Global BioImaging Project -- International imaging infrastructure services for the life science community, 2016-2018
  • FP7-INFRASTRUCTURES-2010-1: Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences, 2012-2014
  • FP7-HEALTH-2013 (602306) MITIGATE: "Closed-loop Molecular Environment for Minimally Invasive Treatment of Patients with Metastatic Gastrointestinal Stromal Tumours"; 2013-2017
  • H2020-INFRADEV-1-2015-2: "Euro-BioImaging Preparatory Phase 2", 2015-2017 (EuBI PP2) (siamo dentro come CNR e non come UNiTO)
  • National project AIRC IG2013: “Dual MRI-Optical imaging agents in prostatectomy”( 2014-2016);
  • Project funded by San Paolo Foundation: “Validation of VHH-type molecules and aptamers for the tumor-specific release of drugs and evaluation of response by functional imaging” (2012-2014)
  • Project funded by San Paolo Foundation: “Innovative Nanosized Theranostic Agents: design, preparartion and preclinical in vivo validation – INTA” (2012-2015);
  • National PRIN project “Innovative chemical tools for improved molecular approaches in biomedicine” (2013-2015);
  • Integrated EU Project “Imaging of Neuroinflammation in Neurodegenerative Diseases – InMIND” (2012-2017);
  • H2020-PHC-2015 project: “GlucoCEST Imaging of Neoplastic Tumours - GLINT” (2016-2020)
  • H2020-PHC-2015 project: “Improving Diagnosis by Fast Field-Cycling MRI - Identify” (2016-2020)
  • H2020-PHC-2015 project: “In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases - SPCCT” (2016-2020)
  • H2020 INFRADEV-2014-2015: “Coordinated Research Infrastructures Building Enduring Life-science services” (CORBEL) (2015-2019)

 

IBFM - Selected publications and grants from last 5 years

  1. Valtorta S, Belloli S, Sanvito F, Masiello V, Di Grigoli G, Monterisi V, Fazio F, Picchio M and Moresco RM. Comparison of 18F-Fluoroazomycin-Arabinofuranoside and 64Cu-Diacetyl-Bis(N4-Methylthiosemicarbazone) in Preclinical Models of Cancer. J Nucl Med. 2013 Jul;54(7):1106-12.
  2. Lo Dico A., Valtorta S., Martelli C. Belloli S., Gianelli U., Tosi D., Bosari S., Degrassi A., Russo M., Todde S., Monterisi C., Lucignani G., Moresco R.M and Ottobrini L. Validation of an engineered cell model for in vitro and in vivo hypoxia evaluation by different imaging modalities. Mol Imaging Biol. 2014 Apr;16(2):210-23.
  3. Valtorta S., Nicolini G, Tripodi F, Meregalli C, Cavaletti G, Avezza F, Crippa L.,  Bertoli G., Fusi P, Pagliarin R, Orsini F, Moresco RM and Coccetti P. A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer. Invest New Drugs 2014 Dec;32(6):1123-33.
  4. Curtarello M, Zulato E, Nardo G, Valtorta S, Guzzo G, Rossi E, Esposito G, Msaki A, Pastò A, Rasola A, Persano L, Ciccarese F, Bertorelle R, Todde S, Plebani M, Schroer H, Walenta S, Mueller-Klieser W, Amadori A, Moresco RM, Indraccolo S. VEGF-Targeted Therapy Stably Modulates the Glycolytic Phenotype of Tumor Cells. Cancer Res. 2015 Jan 1;75(1):120-33.
  5. Lo Dico A, Martelli C, Valtorta S, Raccagni I, Diceglie C, Belloli S, Gianelli, U, Vaira V, Politi LS, Bosari S, Lucignani G, Moresco RM, Ottobrini L. Identification of imaging biomarkers for the assessment of tumour response to different treatments in a preclinical glioma model. Eur J Nucl Med Mol Imaging. 2015 Mar 27.
  6. Di Grigoli G, Monterisi C, Belloli S, Masiello V, Politi L, Valenti S, Paolino M 6, Anzini M, Matarrese M,Cappelli A, Moresco R M. “Radiosynthesis and preliminary biological evaluation of [18F]VC701, a radioligand for Translocator Protein”. Molecular Imaging. Mol Imaging. 2015;1;14(6):7290201500007.
  7. Valtorta S, Moro M, Prisinzano G, Bertolini G, Tortoreto M, Raccagni I, Pastorino U, Roz L, Sozzi G, Moresco RM. Metabolic Evaluation of Non-Small Cell Lung Cancer Patient-Derived Xenograft Models Using 18F-FDG PET: A Potential Tool for Early Therapy Response. J Nucl Med. 2017 Jan; 58(1):42-47.
  8. Gaglio D, Valtorta S, Ripamonti M, Bonanomi M, Damiani C, Todde S, Negri AS,Sanvito F, Mastroianni F, Di Campli A, Turacchio G, Di Grigoli G, Belloli S,Luini A, Gilardi MC, Colangelo AM, Alberghina L, Moresco RM. Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: a PET imaging and metabolomics-mass-spectrometry study. Oncotarget. 2016 Aug 9;7(32):52017-52031.
  9. Belloli S, Pannese M, Buonsanti C, Maiorino C, Di Grigoli G, Carpinelli A,Monterisi C, Moresco RM, Panina-Bordignon P. Early upregulation of 18-kDatranslocator protein in response to acute neurodegenerative damage in TREM2-deficient mice. Neurobiol Aging. 2017 May;53:159-168.
  10. Rainone P, Riva B, Belloli S, Sudati F, Ripamonti M, Verderio P, Colombo M, Colzani B, Gilardi MC, Moresco RM, Prosperi D. Development of 99mTc-radiolabeled nanosilica for targeted detection of HER2-positive breast cancer. International Journal of Nanomedicine. 2017 May 2; 12: 3447—3461.
  • 2° Framework agreement Lombardia-CNR: “MbMM: methodologies for innovation of diagnosis and therapy of multifactorial diseases”. 2013-2015.
  • Progetto Premiale: “Innovatove tecnologies for therapy with radionuclides e biological imaging” (TERABIO). 2015
  • 3° Framework agreement Lombardia-CNR: “Metabolic alterations, cellular stress and neurodegenerative processes - AMANDA”. 2017-2019.
  • Cluster ALISEI, IVASCOMAR: “Identification, validation and commercial development of novel biomarkers fro diagnosis and prognosis of complex diseases”. 2013-2017. 
  • National project AIRC IG-2014: “Multimodal imaging approach for identification of new potential biomarker for treatment response in glioma models” 2015-2017.
  • National project funded by MIUR: “New strategies for diagnostic, therapeutic and clinical care in Neurologic diseases”. 2016-2018.
  • 2017 PRIN-MIUR. “Generation of functional striatal neurons for brain repair in Huntington Disease”. 2017-2019.

 

OSR - Selected publications and grants from last 5 years

  1. Mastaglio, S., Genovese, P., Magnani, Z., Ruggiero, E., Landoni, E., Camisa, B., Schiroli, G., Provasi, E., Lombardo, A., Reik, A., Cieri, N., Rocchi, M., Oliveira, G., Escobar, G., Casucci, M., Gentner, B., Spinelli, A., Mondino, A., Bondanza, A., Vago, L., Ponzoni, M., Ciceri, F., Holmes, M.C., Naldini, L., Bonini, C. “NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease” Blood 2017, 130 (5), pp. 606-618.
  2. Dugnani E, Pasquale V, Liberati D, Citro A, Cantarelli E, Pellegrini S, Marra P, Canu T, Balzano G, Scavini M, Esposito A, Doglioni C, Piemonti L. “Modeling the Iatrogenic Pancreatic Cancer Risk After Islet Autotransplantation in Mouse”. Am J Transplant. 2017;17(10):2720-2727
  3. Locafaro, G., Andolfi, G., Russo, F., Cesana, L., Spinelli, A., Camisa, B., Ciceri, F., Lombardo, A., Bondanza, A., Roncarolo, M.G., Gregori, S. “IL-10-Engineered Human CD4+ Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism” Molecular Therapy 2017, in Press 
  4. Corti A, Gasparri AM, Ghitti M, Sacchi A, Sudati F, Fiocchi M, Buttiglione V, Perani L, Gori A, Valtorta S, Moresco RM, Pastorino F, Ponzoni M, Musco G, Curnis F. “Glycine N-methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing”. Adv Funct Mater. 2017;27(36). pii: 1701245
  5. Curnis F, Dallatomasina A, Bianco M, Gasparri A, Sacchi A, Colombo B, Fiocchi M, Perani L, Venturini M, Tacchetti C, Sen S, Borges R, Dondossola E, Esposito A, Mahata SK, Corti A. “Regulation of tumor growth by circulating full-length chromogranin” A. Oncotarget. 2016;7(45):72716-72732
  6. De Ceglia R, Chaabane L, Biffi E, Bergamaschi A, Ferrigno G, Amadio S, Del Carro U, Mazzocchi N, Comi G, Bianchi V, Taverna S, Forti L, D'Adamo P, Martino G, Menegon A, Muzio L.  “Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate”. Brain Behav Immun. 2015;45:263-76
  7. Sciorati C, Esposito A, Campana L, Canu T, Monno A, Palmisano A, De Cobelli F, Del Maschio A, Ascheman DP, Manfredi AA, Rovere-Querini P “7-Tesla magnetic resonance imaging precisely and noninvasively reflects inflammation and remodeling of the skeletal muscle in a mouse model of antisynthetase syndrome”. Biomed Res Int. 2014;879703
  8. Ferrari G, Bignami F, Giacomini C, Capitolo E, Comi G, Chaabane L, Rama P. “Ocular surface injury induces inflammation in the brain: in vivo and ex vivo evidence of a corneal-trigeminal axis”.  Invest Ophthalmol Vis Sci. 2014;55(10):6289-300
  9. Silvia Maestroni, Anna Maestroni, Simona Ceglia, Gemma Tremolada, Monica Mancino, Angelina Sacchi, Rosangela Lattanzio, Ilaria Zucchiatti, Angelo Corti, Francesco Bandello and Gianpaolo Zerbini, “Effect of chromogranin A-derived vasostatin-1 on laser-induced choroidal neovascularization in the mouse”, in Acta Ophthalmol. 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
  10. Esposito A, Campana L, Palmisano A, De Cobelli F, Canu T, Santarella F,Colantoni C, Monno A, Vezzoli M, Pezzetti G, Manfredi AA, Rovere-Querini P, Del Maschio A. “Magnetic resonance imaging at 7T reveals common events in age-related sarcopenia and in the homeostatic response to muscle sterile injury”. PLoS One. 2013;8(3):e59308
  • Project funded by MIUR: “New nano-systems for targeted delivery of cytokines to tumor”, 2014-2018
  • National project funded by FISM (Italian Foundation for Multiple Schlerosis) “Direct and indirect role of endogenous neural precursor cells in demyelination and remyelination after cuprizone- induced injury”, 2016-2017
  • National project funded by FISM (Italian Foundation for Multiple Schlerosis) “Role of Jab1 and senescence in the pathogenesis of progressive MS in a mouse model”, 2017-2018
  • National project funded by FISM (Italian Foundation for Multiple Schlerosis): “A translational platform for the development of MRI methods to assess myelin architecture”, 2017-2018
  • AIRC 2011/2014:  “In vivo imaging of HMGB1-dependent spreading of ovarian cancer”, 2011-2015

 

FTGM - Selected publications and grants from last 5 years

  1. Aquaro GD, Barison A, Todiere G, Grigoratos C, Ait Ali L, Di Bella G, Emdin M, Festa P. “Usefulness of Combined Functional Assessment by Cardiac Magnetic Resonance and Tissue Characterization Versus Task Force Criteria for Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy”, Am J Cardiol. 2016;118(11):1730-1736.
  2. Lionetti V. “Simultaneous exposure to nitric oxide inhibition and angiotensin II overload: is it a murine model of mitochondrial dysfunction in nonischemic heart failure?”, Am J Physiol Heart Circ Physiol. 2016;310(11):H1385-7.
  3. Neglia D, et. al “EVINCI Study Investigators. Detection of significant coronary artery disease by noninvasive anatomical and functional imaging”, Circ Cardiovasc  Imaging. 2015;8(3).
  4. Giorgetti A, Burchielli S, Positano V, Kovalski G, Quaranta A, Genovesi D, Tredici M, Duce V, Landini L, Trivella MG, Marzullo P. “Dynamic 3D analysis of myocardial sympathetic innervation: an experimental study using 123I-MIBG and a CZT camera”,  J Nucl Med. 2015;56(3):464-9.
  5. Flori A, Liserani M, Frijia F, Giovannetti G, Lionetti V, Casieri V, Positano V, Aquaro GD, Recchia FA, Santarelli MF, Landini L, Ardenkjaer-Larsen JH, Menichetti L.  “Real-time cardiac metabolism assessed with hyperpolarized [1-(13) C]acetate in a large-animal model”, Contrast Media Mol Imaging. 2015;10(3):194-202.
  6. Gimelli A, Masci PG, Liga R, Grigoratos C, Pasanisi EM, Lombardi M, Marzullo P. “Regional heterogeneity in cardiac sympathetic innervation in acute myocardial infarction: relationship with myocardial oedema on magnetic resonance”, Eur J Nucl Med Mol Imaging. 2014;41(9):1692-4.
  7. Masci PG, Doulaptsis C, Bertella E, Del Torto A, Symons R, Pontone G, Barison A, Droogné W, Andreini D, Lorenzoni V, Gripari P, Mushtaq S, EMDIN M, Bogaert J, Lombardi M. “Incremental prognostic value of myocardial fibrosis in patients with non-ischemic cardiomyopathy without congestive heart failure”, Circ Heart Fail.2017;7(3):448-56.
  8. Tinti E, Positano V, Giorgetti A, Marzullo P. “Feasibility of [(123)I]-meta-iodobenzylguanidine dynamic 3-D kinetic analysis in vivo using a CZT ultrafast camera: preliminary results”, Eur J Nucl Med Mol Imaging. 2014;41(1):167-73.
  9. Barison A, Aquaro GD, Masci PG., “Myocardial extracellular volume measurement by cardiac magnetic resonance”, JACC Cardiovasc Imaging. 2014;7(1):106-7.
  10. Lionetti V, Romano SL, Bianchi G, Bernini F, Dushpanova A, Mascia G, Nesti M, Di Gregorio F, Barbetta A, Padeletti L, “Impact of acute changes of left ventricular contractility on the transvalvular impedance: validation study by pressure-volume loop analysis in healthy pigs”, PLoS One. 2013, 19;8(11):e80591.
  • National project MIUR-Regione Toscana: "Ricerca Finalizzata 2011/2012”:  “Establishment of Valid Pediatric Echocardiographic Nomograms: An Essential and Surprisingly Lacking Tool for the Quantification in The Performance of a Pediatric Echocardiography”. 2013-running.
  • National project MIUR-Regione Toscana: "Ricerca Finalizzata 2011/2012”:  CARPEDIEM - Comorbidity And Risk Profiles Evaluation in Diabetes and hEart Morbidities. 2013-running.
  • National project MIUR-Regione Toscana "Bando Ricerca Finalizzata e Giovani Ricercatori 2010": Hyperpolarized 13C-Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure. 2010-running.
  • National project MIUR-Regione Toscana "Bando Ricerca Finalizzata e Giovani Ricercatori 2013 - “Exploring the potentialities of lung ultrasound in pediatric cardiac surgery: an easy, fast, inexpensive, radiation-free, but still surpringly underutilized diagnostic tool”. 2013-running.
  • National project MIUR-Regione Toscana "Bando Ricerca Finalizzata e Giovani Ricercatori 2011/2012 - Virtual and Augmented Reality Support for Transcatheter Valve Implantation Using Cardiovascular MRI. 2014-running.
  • Horizon 2020 UE-SMARTool - Project Title: Simulation Modeling of coronary ARTery disease: a tool for clinical decision support. 2016-2019.

 

UNIPI - Selected publications and grants from last 5 years

  1. Ciarrocchi, E., Belcari, N. “Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences” EJNMMI Physics, 2017, 4 (1), art. no. 14.
  2. Nicola Belcari; Niccolò Camarlinghi; Stefano Ferretti; Patricia Iozzo; Daniele Panetta; Piero A. Salvadori; Giancarlo Sportelli; Alberto Del Guerra “NEMA NU-4 Performance Evaluation of the IRIS PET/CT Preclinical Scanner”, IEEE Transactions on Radiation and Plasma Medical Sciences 2017, Volume: 1, Issue: 4, Pages: 301 - 309
  3. Bisogni, M.G., Attili, A., Battistoni, G., Belcari, N., Camarlinghi, N., Cerello, P., Coli, S., Del Guerra, A., Ferrari, A., Ferrero, V., Fiorina, E., Giraudo, G., Kostara, E., Morrocchi, M., Pennazio, F., Peroni, C., Piliero, M.A., Pirrone, G., Rivetti, A., Rolo, M.D., Rosso, V., Sala, P., Sportelli, G., Wheadon, R. “ INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy” Journal of Medical Imaging 2017, 4 (1), art. no. 011005.
  4. Rosso, V., Belcari, N., Bisogni, M.G., Camarlinghi, N., Cirrone, G.A.P., Collini, F., Cuttone, G., Guerra, A.D., Milluzzo, G., Morrocchi, M., Raffaele, L., Romano, F., Sportelli, G., Zaccaro, E. “ DoPET: An in-treatment monitoring system for proton therapy at 62 MeV” Journal of Instrumentation 2016, 11 (12), art. no. C12029.
  5. Panetta, D., Belcari, N., Tripodi, M., Burchielli, S., Salvadori, P.A., Del Guerra, A. “ Performance evaluation of the CT component of the IRIS PET/CT preclinical tomograph”, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016, 805, pp. 135-144.
  6. Vanhove, C., Bankstahl, J.P., Krämer, S.D., Visser, E., Belcari, N., Vandenberghe, S. “Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance”, EJNMMI Physics, 2015, 2 (1), art. no. 31, pp. 1-25.
  7. Ciarrocchi, E., Belcari, N., Del Guerra, A., Cherry, S.R., Lehnert, A., J. Hunter, W.C., McDougald, W., Miyaoka, R.S., Kinahan, P.E. “ Cherenkov luminescence measurements with digital silicon photomultipliers: a feasibility study”, EJNMMI Physics, 2015, 2 (1), art. no. 32, pp. 1-22.
  8. Sportelli, G., Belcari, N., Camarlinghi, N., Cirrone, G.A.P., Cuttone, G., Ferretti, S., Kraan, A., Ortuño, J.E., Romano, F., Santos, A., Straub, K., Tramontana, A., Guerra, A.D., Rosso, V. “First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system”, Physics in Medicine and Biology, 2015, 59 (1), pp. 43-60.
  9. Cecchetti, M., Moehrs, S., Belcari, N., Guerra, A.D. “ Accurate and efficient modeling of the detector response in small animal multi-head PET systems”, Physics in Medicine and Biology 2013, 58 (19), pp. 6713-6731.
  10. Pagliazzi, M., Ciarrocchi, E., Del Guerra, A., Belcari, N., Boschi, F., Spinelli, A.E. “ Development of a simulation environment for Cerenkov luminescence imaging” IEEE Nuclear Science Symposium Conference Record, 2013, art. no. 6829367.
  • FP7-COOPERATION. FP7-HEALTH-2013-INNOVATION-1: “A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia (TRIMAGE)”, 2014-2018
  • EC/Regione Toscana, ERANET-COFUND PhotonicSensing” Ultra-Time-Of-Flight Positron Emission Tomography with multi-channel digital Silicon photomultipliers and photonic crystals (UTOFPET)”, 2018-2020
  • Project funded by Inviscan s.a.s.: “Development of the pre-clinical imaging system IRIS PET/CT”, 2013-running

 

IFC - Selected publications and grants from last 5 years

  1. F. Ratto, S. Centi, C. Avigo, C. Borri, F. Tatini, L. Cavigli, C. Kusmic, B. Lelli, S. Lai, M. Benagiano, M. M. D'Elios, S. Colagrande, F. Faita, L. Menichetti, R. Pini A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging. Advanced Functional Materials, 26(39):7178-7185; ERRATA CORRIGE: F. Ratto, S. Centi, C. Avigo, C. Borri, F. Tatini, L. Cavigli, C. Kusmic, B. Lelli, S. Lai, M. Benagiano, M. M. D'Elios, S. Colagrande, F. Faita, L. Menichetti, R. Pini, A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging. Advanced Functional Materials, 26(44):7954
  2. N. Di Lascio, C. Kusmic, F. Stea, F. Lenzarini, C. Barsanti, A. Leloup, F. Faita, Longitudinal micro-ultrasound assessment of the ob/ob mouse model: Evaluation of cardiovascular, renal and hepatic parameters, International journal of obesity, doi:10.1038/ijo.2017.219
  3. Luchini, A., Irace, C., Santamaria, R., Montesarchio, D., Heenan, R.K., Szekely, N., Flori, A., Menichetti, L., Paduano, L. Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: Defining the structure and probing: In vivo applications (2016) Nanoscale, 8 (19), pp. 10078-10086.
  4. Panetta D, Belcari N, Tripodi M, Burchielli S, Salvadori PA, Del Guerra A. Performance evaluation of the CT component of the IRIS PET/CT preclinical tomograph. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2016;805:135-44.
  5. Belcari N, Camarlinghi N, Panetta D, Iozzo P, Burchielli S, Salvadori PA, et al. Multimodal 4D cardiac imaging with the preclinical IRIS PET/CT scanner. European Journal of Nuclear Medicine and Molecular Imaging. 2016;43:S514-S.
  6. Camarlinghi N, Luongo C, Belcari N, Panetta D, Iozzo P, Burchielli S, et al. Performance evaluation of the step and shoot acquisition modality of the IRIS PET scanner. European Journal of Nuclear Medicine and Molecular Imaging. 2016;43:S503-S.
  7. Guzzardi MA, Liistro T, Gargani L, Ait Ali L, D'Angelo G, Rocchiccioli S, La Rosa F, Kemeny A, Sanguinetti E, Ucciferri N, De Simone M, Bartoli A, Festa P, Salvadori PA, Burchielli S, Sicari R, Iozzo P. Maternal Obesity and Cardiac Development in the Offspring: Study in Human Neonates and Minipigs. JACC Cardiovasc Imaging. 2017 Nov 10. pii: S1936-878X(17)30906-3.
  8. Gastaldelli A, Gaggini M, Daniele G, Ciociaro D, Cersosimo E, Tripathy D, Triplitt C, Fox P, Musi N, DeFronzo R, Iozzo P. Exenatide improves both hepatic and adipose tissue insulin resistance: A dynamic positron emission tomography study. Hepatology. 2016 Dec;64(6):2028-2037.
  9. Guzzardi MA, Iozzo P, Salonen MK, Kajantie E, Eriksson JG. Maternal adiposity  and infancy growth predict later telomere length: a longitudinal cohort study. Int J Obes (Lond). 2016 Jul;40(7):1063-9.
  10. Sanguinetti E, Liistro T, Mainardi M, Pardini S, Salvadori PA, Vannucci A, Burchielli S, Iozzo P. Maternal high-fat feeding leads to alterations of brain glucose metabolism in the offspring: positron emission tomography study in a porcine model. Diabetologia. 2016 Apr;59(4):813-21
 

IFC Grants will be published soon

 

SDN - Selected publications and grants from last 5 years

  1. Catalano, O. A., Daye, D., Signore, A., Iannace, C., Vangel, M., Luongo, A., ... & Salvatore, M. et al. Staging performance of whole-body DWI, PET/CT and PET/MRI in invasive ductal carcinoma of the breast. International Journal of Oncology 2017, 51(1), 281-288.
  2. Cavaliere, C., Romeo, V., Aiello, M., Mesolella, M., Iorio, B., Barbuto, L., ... & Covello, M. Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer. European Journal of Radiology 2017, 88, 47-55.
  3. Catalano, O. A., Nicolai, E., Rosen, B. R., Luongo, A., Catalano, M., Iannace, C., ... & Salvatore, M. Comparison of CE-FDG-PET/CT with CE-FDG-PET/MR in the evaluation of osseous metastases in breast cancer patients. British journal of cancer 2015, 112(9), 1452-1460.
  4. Covello, M., Cavaliere, C., Aiello, M., Cianelli, M. S., Mesolella, M., Iorio, B., ... & Nicolai, E. Simultaneous PET/MR head–neck cancer imaging: Preliminary clinical experience and multiparametric evaluation. European journal of radiology 2015, 84(7), 1269-1276.
  5. Aiello, M., Salvatore, E., Cachia, A., Pappatà, S., Cavaliere, C., Prinster, A., ... & Quarantelli, M. Relationship between simultaneously acquired resting-state regional cerebral glucose metabolism and functional MRI: a PET/MR hybrid scanner study. Neuroimage 2015, 113, 111-121.
  6. Nappi, C., Altiero, M., Imbriaco, M., Nicolai, E., Giudice, C. A., Aiello, M., ... & Cuocolo, A. First experience of simultaneous PET/MRI for the early detection of cardiac involvement in patients with Anderson-Fabry disease. European journal of nuclear medicine and molecular imaging 2015, 42(7), 1025-1031.
  7. Catalano, Onofrio A., et al. "Evaluation of quantitative PET/MR enterography biomarkers for discrimination of inflammatory strictures from fibrotic strictures in Crohn disease." Radiology 2015: 792-800.
  8. Pace, Leonardo, et al. "Comparison of whole-body PET/CT and PET/MRI in breast cancer patients: lesion detection and quantitation of 18F-deoxyglucose uptake in lesions and in normal organ tissues." European journal of radiology 2014: 289-296.
  9. Catalano, O. A., Rosen, B. R., Sahani, D. V., Hahn, P. F., Guimaraes, A. R., Vangel, M. G., ... & Salvatore, M. Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients—a hypothesis-generating exploratory study. Radiology 2013, 269(3), 857-869.
  10. Pace, L., Nicolai, E., Aiello, M., Catalano, O. A., & Salvatore, M. Whole-body PET/MRI in oncology: current status and clinical applications. Clinical and Translational Imaging 2013, 1(1), 31-44.
  • National project PON03PE_00146 - BIBIOFAR: “Innovative biomarkers, biomaterials and drugs for Diagnosis and Therapy of cerebral ischemy and pluriresistentant Tumors of the head, neck and breast by the realization of a Biobanks network”, 2013-2016.
  • National project PON03_00093 - BIOSCIENCE_MEDIA: “High efficiency diagnostic methodologies for the osteoarticular patient: non invasive pre and post-operatory MR Imaging in the implantation of prothesis and integrated systems supporting the clinical/diagnostic data management”, 2013-2017.
  • National project PON03PE_00128 - eHealthNet: Software ecosystem for Electronic Health system, 2013-2017.
  • National project POR Campania 2007-2013 Misura 2.1 BERSAGLI: Targets, probes and signals in therapy and diagnostics, 2009-2015.
  • National project PON03PE_00128 - eHealthNet: Ecosistema software per la Sanità Elettronica Bando Trasferimento Tecnologico e di Prima Industrializzazione Sportello dell’innovazione. "MEDICO - MEdical DIagnosis based on Collaboration", 2014-2016.
  • National project PHARMACOG IMI_Pharma-Cog: “Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in early clinical development”, 2012-2015.
  • National project “Grandi Progetti R&S – PON 2014/2020”  - “Big Data” and genomic imaging for the development of biomakers and innovative nanovectorial drugs for disagnosis and therapy of inflammatory processes in dementia (BigImAGING), 2017-2019.
  • National project “Grandi Progetti R&S – PON 2014/2020”  - “Big Data Analytics for Personal Health Record” (BDA4PHR), 2017-2018.

 

IBB - Selected publications and grants from last 5 years

  1. Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S. Monitoring reversal of MET-mediated resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer using 3’-deoxy-3’-[18F]-fluorothymidine positron emission tomography. Clin Cancer Res 2014; doi: 10.1158/1078-0432. CCR-14-0264.
  2. Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A. Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer. Theranostics (ISSN: 1838-7640electronic, 1838-7640linking), 2017 Aug 22; 7(14): 3595-3607.
  3. Erro R, Pappata S, Picillo M, Rocco M, Santangelo G, Barone P, Vitale C. Teaching NeuroImages: Pseudo-abnormal DaTscan findings in meningioma-induced parkinsonism. Neurology (ISSN: 0028-3878, 1526-632x), 2013 Mar 26; 80(13): e147-e147.
  4. Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dollé F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappatà S. Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with 18F-DPA-714 and micro-PET/CT. Eur J Nucl Med Mol Imaging. 2016, 43 (7): 1348-59
  5. Albanese S, Auletta L, Zannetti A, Di Maro G, Mirabelli P, D'Alterio C, Salvatore G, Soricelli A, Salvatore M, Greco A. High Frequency Ultrasound for the development of an Orthotopic mouse model of Human Follicular Thyroid Carcinoma. Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2015; 42: S416-S416.
  6. Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M. Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
  7. Morbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Jafari L, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H. Erratum to: The need of standardization and of large clinical studies in an emerging indication of [18 F]FDG PET: the autoimmune encephalitis. Eur J Nucl Med Mol Imaging (ISSN: 1619-7089electronic, 1619-7070linking, 1619-7070print), 2017 Mar; 44(3): 559-560.
  8. Vicidomini C, Vinciguerra A, Greco A, Panico M, Gargiulo S, Gramanzini M, Coda ARD, Pignataro G, Quarantelli M, Tavitian B, Dollé F, Brunetti A, Salvatore M, Annunziato L, Pappata S. Imaging of brain TSPO expression in a mouse model of stroke with [18F]DPA-714 and micro-PET. Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: 450-450.
  9. Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A. A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion. Cancer Lett (ISSN: 1872-7980electronic, 0304-3835linking), 2015 Oct 27; 370(1): 100-107.
  10. Hill BS, Pelagalli A, Passaro N, Zannetti A. Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype. Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Aug 14; 8(42): 73296-73311.
  • National PRIN project “Lab on fIber technology For advanced optical nanoprobEs (LIFE)”, 2016-2018.
  • National PRIN project “Regenerative potential of extracellular vesicles-derived from mesenchymal stem cells on epithelial wound healing”, 2016-2018.
  • National F.I.R.S.T. SIR project: “Learning from diabetes to treat Alzheimer's disease: a role for HSP60 in the regulation of brain IGF-I receptor signaling”, 2015-2018.
  • National F.I.R.B. project “Spectroscopic and structural characterization of proteosoma inhibitors”, 2013-2017.
  • Regional project (Regione Campania Legge 5): “Study of the correlations structure-activity in bioactive compounds from traditional Chinese plants”, 2014-2016.
  • Regional P.O.R. project “Targets, probes and signals in diagnostics and therapy”, 2013-2016
  • National PRIN project “New imaging techniques in the study of cerebral perfusion alterations in neuronal degenerative processes in patients with multiple sclerosis and other degenerative neurologic pathologies”, 2013-2016.
  • National PRIN project: “Functional organization at nanoscopic level of (bio)molecules and hybrid systems for applications in the fields of sensors, medicine and biotechnologies”, 2013-2016.
  • National F.I.R.B. Project: “Detection of ionizing radiation by optical fibers sensors”, 2012-2016.
  • National F.I.R.B. project: “Alterations of the beta-adrenergic system, mitochondrial stress and epigenetic changes in the cardiac deficiency: new diagnostic and therapeutic molecular approaches”
  • National PRIN project: “Monitoring of peripheral levels of a microRNA pool, by the development of a multiprobe device based on optical fiber nanosensors, for the diagnosis and prognosis of brain ischemia”.